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Review

Pharmacological profiles of Gynostemma Pentaphyllum: A therapeutic candidate from Jeju
Chan-Hyuk Kwon1
,
Hyoji Choi2
,
Sumi Lee3*
,
Min Woo Ha24*
1Seoul Shingil Rehabilitation Medicine Clinic, Seoul 07362, Republic of Korea
2Jeju Research Institute of Pharmaceutical Sciences, College of Pharmacy, Jeju National University, Jeju 63243, Republic of Korea
3School of Pharmacy and Institute of New Drug Development, Jeonbuk National University, Jeonju 54907, Republic of Korea
4SynBioChem convergence Institute, Jeju National University, Jeju 63243, Republic of Korea
*Corresponding Author
29 August 2025. pp. 50-59
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Abstract

Gynostemma pentaphyllum, a distinctive plant species that thrives in the unspoilt natural environment of Jeju Island, is referred to by some as “the poor's ginseng”. This plant has long been highly valued for its distinctive flavor and numerous health benefits, including antioxidant, anti-inflammatory, and immune-boosting properties. Its pharmacological potential is currently being assessed using modern analytical approaches, and in this paper, we review the findings of recent pharmacological research conducted from 2022 to the present on the bioactive compounds of G. pentaphyllum from Jeju and their efficacy. It is anticipated that unlocking the molecular secrets of nature's gift to this barren island will lead to the development of new medicines from Jeju.

Keywords
Gynostemma pentaphyllum
Therapeutics
Natural Product
Jeju Island
Gypenosides
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Information
  • Publisher :Jeju Journal of Island Sciences
  • Publisher(Ko) :제주섬과학회지
  • Journal Title :Jeju Journal of Island Sciences
  • Journal Title(Ko) :제주섬과학회지
  • Volume : 2
  • No :2
  • Pages :50-59
  • Received Date : 2025-06-24
  • Revised Date : 2025-07-29
  • Accepted Date : 2025-07-30
  • DOI :https://doi.org/10.23264/JJIS.2025.2.2.050
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