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Review
- Impact of milk processing on bioactive components and anti-inflammatory activity
- Seo-Young Ryu, Md. Meraj Ansari, Young-Ok Son
- Milk proteins are increasingly recognized as bioactive macromolecules that modulate immune and inflammatory pathways beyond their established nutritional role. This review highlights …
- Milk proteins are increasingly recognized as bioactive macromolecules that modulate immune and inflammatory pathways beyond their established nutritional role. This review highlights current evidence on how industrial processing, particularly thermal treatment and microbial fermentation, reshapes the structural and functional landscape of milk proteins and thereby influences their anti-inflammatory potential. Major milk protein fractions, including caseins, whey proteins, lactoferrin, α-lactalbumin and β-lactoglobulin, regulate inflammatory responses through coordinated mechanisms involving suppression of pro-inflammatory cytokine production, modulation of innate and adaptive immune cell activation, enhancement of cellular antioxidant defenses, and remodeling of the gut microbial ecosystem. Processing-induced conformational transitions, aggregation dynamics and proteolytic fragmentation critically determine peptide bioavailability and receptor-level interactions. Heat treatment exerts context-dependent effects by altering tertiary structure, epitope accessibility and redox-sensitive residues, whereas lactic acid bacteria–driven fermentation promotes controlled proteolysis, generating bioactive peptides with defined immunomodulatory activities. Overall, this review highlights the critical role of processing conditions in shaping the anti-inflammatory properties of milk proteins and offers insights for developing dairy products with enhanced health benefits. - COLLAPSE
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Review
- Genetic diversity and its role in seagrass restoration: A review
- Duc-Duy Nguyen, Thanh-Huy Nguyen, Phuong-Thao Tran, Xuan-Vy Nguyen
- Seagrass beds play a crucial role in coastal zones, providing ecosystem services such as carbon storage, water purification, and habitat for marine …
- Seagrass beds play a crucial role in coastal zones, providing ecosystem services such as carbon storage, water purification, and habitat for marine life. However, they have been declining because of multiple stressors. Restoration is a widely used strategy to recover the seagrass beds. In recent years, genetic diversity and population structure of both donor and sink populations have become essential for effective restoration and conservation purposes. This review links global knowledge on seagrass degradation, restoration, and the role of genetic diversity to the context of Viet Nam, with the aim to provide valuable insights for advancing seagrass restoration efforts in the country. - COLLAPSE
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Review
- Recent developments in the pharmacological spectrum of pachymic acid from Poria cocos
- Yesol Kang, Yeonie Yoo, Chan-Hyuk Kwon, Sumi Lee, Min Woo Ha
- Pachymic acid (PA) is a major triterpenoid component extracted from Poria cocos (PC), a fungus used in traditional medicine. PA has attracted …
- Pachymic acid (PA) is a major triterpenoid component extracted from Poria cocos (PC), a fungus used in traditional medicine. PA has attracted attention due to its wide range of beneficial biological effects, including anti-inflammatory, antioxidant, anticancer, immunomodulatory, neuroprotective, and metabolic regulatory functions. Numerous studies have demonstrated its therapeutic potential, showing that PA suppresses inflammatory responses, inhibits cancer cell proliferation, and regulates autophagy by acting on multiple cellular signaling pathways such as NF-κB, MAPK, PI3K/Akt, and AMPK. In addition, PA exhibits low cytotoxicity and possesses structural characteristics common in natural product-derived drug candidates, making it a promising candidate for development. While a milestone review in 2022 consolidated the pharmacological understanding of PA, the rapid influx of new data and certain findings previously overlooked in earlier reports necessitate a contemporary synthesis. In this review, we provide a non-redundant and updated overview by analyzing literature published between 2022 and 2025, while incorporating significant data not fully captured in previous reviews. Based on these findings, we discuss the evolving pharmacological profiles of PA and its prospective applications in therapeutic development. - COLLAPSE
Jeju Journal of Island Sciences
Jeju Journal of Island Sciences
제주섬과학회지
102, Jejudaehak-ro, Jeju-si, Jeju-do, Republic of Korea
Tel: +82-64-754-8308 / E-mail: myyang@jejunu.ac.kr Copyright© Jeju Journal of Island Sciences. Powered by APUB
Tel: +82-64-754-8308 / E-mail: myyang@jejunu.ac.kr Copyright© Jeju Journal of Island Sciences. Powered by APUB